MyBioSource.com's CD8a antibody (biotin) is a Rat monoclonal antibody. The CD8a antibody (biotin) was generated using CD8, and CD8A as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Immunoprecipitation.
Description
Rat monoclonal CD8a antibody (biotin)
CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified